clinical guidelines for multiparametric prostate magnetic resonance (mr) imaging  (AdMeTech Co Ltd)

Journal: Radiology

Article Title: Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma 1

doi: 10.1148/radiol.2017162827

Figure Lengend Snippet: Mapping between three-dimensional prostate whole mounts and multiparametric MR imaging. Tissue sections from whole-mount slides correspond to different regions of interest: adenocarcinoma (Gleason score, ≥3+4) in red outline; moderately suspicious according to multiparametric MR imaging in blue outline; and mildly suspicious by multiparametric MR imaging in yellow outline. The nodule of interest (arrowheads) is shown in each of the fields of view, which are, from left to right: axial T2-weighted image, apparent diffusion coefficient map, spectroscopy profile, and coronal T2-weighted images (which map to the corresponding axial multiparametric MR imaging images and histologic sections), and annotated whole-mount section. The red outlined images highlight a cancer nodule in the right apical posterior peripheral zone: adenocarcinoma with radiologic and pathologic-analysis concordance with abnormal T2 signal, positive diffusion restriction with apparent diffusion coefficient of 1015 mm2/sec, and abnormal spectroscopy (ie, reversal of choline and creatine-to-citrate ratio) that was sectioned and whole-exome sequenced according to the dotted black line in the tissue section (right-hand side). The blue outlined images depict a lesion moderately suspicious for cancer (that was normal according to histopathologic analysis) but with abnormal hypointense T2 signal, apparent diffusion coefficient of 1347 mm2/sec reflecting some restricted diffusion, and normal spectroscopy. The yellow outlined images highlight a histologically normal nodule with abnormal T2 signal hypointensity but no evidence or diffusion or spectroscopic abnormalities.

Article Snippet: Preoperative 3-T pelvic multiparametric MR imaging (Siemens, Erlangen, Germany) with endorectal coils was performed on all patients.

Techniques: Imaging, Diffusion-based Assay, Spectroscopy

Journal: Radiology

Article Title: Multiregional Radiogenomic Assessment of Prostate Microenvironments with Multiparametric MR imaging and DNA Whole-Exome Sequencing of Prostate Glands with Adenocarcinoma 1

doi: 10.1148/radiol.2017162827

Figure Lengend Snippet: One-way hierarchical clustering of multiparametric features across 23 regions of interest in six patients show radiologic and pathologic (path) concordance. Red colored blocks reflect abnormal feature values (eg, decreased T2 signal intensity, decreased diffusion, wash-in and/or wash-out enhancement characteristics, and abnormal spectroscopy) and yellow blocks reflect normal parameter measurements. The two principle branches of the dendrogram across the x-axis segregate the samples into normal and abnormal according to histopathologic analysis, with multiparametric MR imaging classified samples mildly and moderately suspicious for cancer intermixed among the two principle groups. Ktrans = volume transfer constant.

Article Snippet: Preoperative 3-T pelvic multiparametric MR imaging (Siemens, Erlangen, Germany) with endorectal coils was performed on all patients.

Techniques: Diffusion-based Assay, Spectroscopy, Imaging